DNA damage tolerance: when it's OK to make mistakes
نویسندگان
چکیده
منابع مشابه
Why markets make mistakes
Many models of markets are based on assumptions of rationality, transparency, efficiency, and homogeneity in various combinations. They assume, at least implicitly, that decision makers understand the structure of the market and how it produces the dynamics which can be observed or might potentially occur. Are these models acceptable simplifications, or can they be seriously misleading? The res...
متن کاملMechanism Micues to Avoid: Common Mistakes Students Make When Writing Mechanisms
Throughout this course arrow pushing is used to indicate the flow of electrons in the various organic reaction mechanisms that are discussed. A few simple rules for properly performing arrow pushing were introduced in Section 6.2. In this Appendix we examine some of the most common mistakes that students make when first learning arrow-pushing methods and tell you how to avoid them. The mistakes...
متن کاملMechanism of DNA damage tolerance.
DNA damage may compromise genome integrity and lead to cell death. Cells have evolved a variety of processes to respond to DNA damage including damage repair and tolerance mechanisms, as well as damage checkpoints. The DNA damage tolerance (DDT) pathway promotes the bypass of single-stranded DNA lesions encountered by DNA polymerases during DNA replication. This prevents the stalling of DNA rep...
متن کاملWhy Do Borrowers Make Mortgage Refinancing Mistakes?
Refinancing a mortgage is often one of the biggest and most important financial decisions that people make. Borrowers need to choose the interest rate differential at which to refinance and, when that differential is reached, they need to take the steps to refinance before rates change again. The optimal differential is where the interest saved by refinancing equals the sum of refinancing costs...
متن کاملDNA Damage and Its Links to Neurodegeneration
The integrity of our genetic material is under constant attack from numerous endogenous and exogenous agents. The consequences of a defective DNA damage response are well studied in proliferating cells, especially with regards to the development of cancer, yet its precise roles in the nervous system are relatively poorly understood. Here we attempt to provide a comprehensive overview of the con...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2009
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.139